Disney Cruise Line
106 departures · 2 ships · 3 to 14 nights
Disney Magic and Disney Wonder sail from San Diego, covering Baja and Ensenada, Mexican Riviera and Sea of Cortez, Panama Canal, and Pacific coast.
from
$614
Operators
Cruise lines sailing from San Diego
7 lines sail from the Port of San Diego in the period we track. Disney Cruise Line runs the most departures, 106 of 232. A few more lines appear on the port's schedule, among them Virgin Voyages, MSC, Costa and Oceania. On every date we checked, their ships only call at San Diego partway through a voyage that starts somewhere else, so there is no cruise to list from here. The same goes for most of Princess's calls.
Schedule last updated 2026-10-23 · 232 departures listed · Dates can change. Verify with the cruise line before booking.
Holland America Line
68 departures · 6 ships · 4 to 90 nights
Eurodam, Koningsdam, Nieuw Amsterdam, Oosterdam, Zaandam, and Zuiderdam sail from San Diego, covering Pacific coast, Hawaii and South Pacific, Mexican Riviera and Sea of Cortez, Panama Canal, Other itineraries, and Baja and Ensenada.
from
$399
Royal Caribbean International
43 departures · 1 ship · 3 to 15 nights
Serenade of the Seas sail from San Diego, covering Mexican Riviera and Sea of Cortez, Baja and Ensenada, Pacific coast, and Panama Canal.
from
$219.19
Norwegian Cruise Line
9 departures · 1 ship · 6 to 16 nights
Norwegian Star sail from San Diego, covering Mexican Riviera and Sea of Cortez and Panama Canal.
from
$459
Crystal
3 departures · 1 ship · 9 to 15 nights
Crystal Serenity sail from San Diego, covering Mexican Riviera and Sea of Cortez and Other itineraries.
Fares not recorded
See the schedule →
Azamara
2 departures · 1 ship · 17 to 35 nights
Azamara Quest sail from San Diego, covering Panama Canal.
from
$4,089
Princess Cruises
1 departures · 1 ship · 16 nights
Island Princess sail from San Diego, covering Panama Canal.
from
$1,919
Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-10-23. Fares change often, so check the current price before you book.
