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San Diego Cruise Schedule

Cruise line

Royal Caribbean International cruises from San Diego

Royal Caribbean International has 43 departures from the Port of San Diego in the period we cover, on one ship: Serenade of the Seas.

They run from 3 to 15 nights and go to the Mexican Riviera and the Sea of Cortez, Baja California and Ensenada, the Pacific coast, and the Panama Canal.

The cheapest Royal Caribbean International sailing we list is Serenade of the Seas on Thu, Dec 3, 2026, from $219.19 per person.

Royal Caribbean International can move ships and change routes, and the fares here are starting prices rather than quotes. Confirm both with the line.

Schedule last updated 2026-10-23 · 43 departures listed · Dates can change. Verify with the cruise line before booking.

What Royal Caribbean International runs from San Diego

All routes

The 43 departures below run a smaller number of distinct itineraries. Cheapest per night first.

Distinct itineraries available, cheapest per night first
ItineraryNightsFrom
7-Night Cabo Overnight, Catalina & Ensenada

Calls at Catalina Island (California) · Ensenada (Mexico) · Cabo San Lucas (Mexico)

Next on Sun, Dec 13, 2026

7$388.8$56 a night
4-Night Catalina & Ensenada

Calls at Catalina Island (California) · Ensenada (Mexico)

Next on Sun, Nov 29, 2026

4$229$57 a night
7-Night Ensenada, Cabo & La Paz

Calls at La Paz (Mexico) · Cabo San Lucas (Mexico) · Ensenada (Mexico)

Next on Sun, Oct 25, 2026

7$419$60 a night
7-Night Ensenada, Cabo & Mazatlan

Calls at Ensenada (Mexico) · Cabo San Lucas (Mexico) · Mazatlán (Mexico)

Next on Sun, Nov 1, 2026

7$507$72 a night
3-Night Ensenada

Calls at Ensenada (Mexico)

Next on Thu, Dec 3, 2026

3$219.19$73 a night
7-Night Cabo, Mazatlan & La Paz

Calls at Cabo San Lucas (Mexico) · La Paz (Mexico) · Mazatlán (Mexico)

Next on Sun, Nov 22, 2026

7$719$103 a night
7-Night Cabo, Mazatlan & La Paz Holiday

Calls at Cabo San Lucas (Mexico) · La Paz (Mexico) · Mazatlán (Mexico)

Next on Sun, Dec 20, 2026

7$1,019$146 a night
15-Night Panama Canal Eastward

Calls at Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) · Grand Cayman

Ends in Tampa (Florida)

Next on Thu, Oct 7, 2027

15$2,259.27$151 a night

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-10-23. Fares change often, so check the current price before you book.

What Royal Caribbean International is advertising

Promotions Cruisebound lists for Royal Caribbean International, confirmed on 2026-10-23. These are the advertiser's terms, not ours, and whether one applies to a particular San Diego sailing depends on the cabin, the date and how many of you are travelling. The fares in the table above are what we recorded ourselves and do not include any of this.

Discounts that depend on who you are rather than what you book, for military, first responders, residents of qualifying states and guests over 55, are claimed with the cruise line itself. They are not part of the above, and a booking site cannot apply them for you.

6 more are listed. See Royal Caribbean International sailings from San Diego on Cruisebound. Links in this section are paid: we earn a commission if you book, at no cost to you, and it does not change which sailings this site lists or how they are ordered.

Every departure by date

Royal Caribbean International by month

Where these sailings go

Cruise line website: Royal Caribbean International. Confirm dates and fares there before you book.