Destination

Other itineraries cruises from San Diego

One-way voyages down the Pacific coast of Central and South America. Crystal Serenity ends in Callao, the port for Lima. Holland America's Nieuw Amsterdam goes on to Chile, and the longer of its two voyages carries on through the Chilean fjords and the Falklands to Buenos Aires.

There are 3 such sailings on the board, running 15 to 36 nights, operated by Crystal and Holland America Line aboard Crystal Serenity and Nieuw Amsterdam. The lowest recorded starting fare is $2,784 per person, on the Tue, Oct 12, 2027 departure.

Ports of call

Cabo San Lucas (Mexico)3 Puntarenas (Costa Rica)3 Manta (Ecuador)3 Salaverry (Peru)3 Huatulco (Mexico)2 Puerto Quetzal (Guatemala)2 Callao (Peru)2 General San Martin (Peru)2 Arica (Chile)2 Coquimbo (Chile)2 Mazatlán (Mexico)1 Puerto Vallarta (Mexico)1 Acajutla (El Salvador)1 Playa Flamingo (Costa Rica)1 Guayaquil (Ecuador)1 San Antonio (Chile)1 Puerto Montt (Chile)1 Puerto Chacabuco (Chile)1 Chilean fjords1 Pío XI Glacier (Chile)1 Punta Arenas (Chile)1 Stanley (Falkland Islands)1 Montevideo (Uruguay)1

Schedule last updated 2026-10-23 · 3 departures listed · Dates can change. Verify with the cruise line before booking.

Your Other itineraries options

All routes

The 3 departures below run a smaller number of distinct itineraries. Cheapest per night first.

Distinct itineraries available, cheapest per night first
Itinerary	Ship	Nights	Departures	From
36-Night South America Calls at Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) · San Antonio (Chile) · Puerto Montt (Chile) · Puerto Chacabuco (Chile) · Chilean fjords · Pío XI Glacier (Chile) · Punta Arenas (Chile) · Stanley (Falkland Islands) · Montevideo (Uruguay) Ends in Buenos Aires (Argentina) Next on Tue, Oct 12, 2027	Nieuw Amsterdam	36	1	$4,249$118 a night
21-Night South America Calls at Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) Ends in San Antonio (Chile) Next on Tue, Oct 12, 2027	Nieuw Amsterdam	21	1	$2,784$133 a night
15-Night San Diego to Callao Calls at Cabo San Lucas (Mexico) · Mazatlán (Mexico) · Puerto Vallarta (Mexico) · Acajutla (El Salvador) · Playa Flamingo (Costa Rica) · Puntarenas (Costa Rica) · Manta (Ecuador) · Guayaquil (Ecuador) · Salaverry (Peru) Ends in Callao (Peru) Next on Fri, Jan 8, 2027	Crystal Serenity	15	1	Not recorded

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-10-23. Fares change often, so check the current price before you book.

Every departure by date

Other itineraries sailings from the Port of San Diego
Departs	Ship	Line	Nights	Itinerary & ports	From
Fri, Jan 8, 2027 endsSat, Jan 23, 2027	Crystal Serenity	Crystal	15	15-Night San Diego to Callao Calls at Cabo San Lucas (Mexico) · Mazatlán (Mexico) · Puerto Vallarta (Mexico) · Acajutla (El Salvador) · Playa Flamingo (Costa Rica) · Puntarenas (Costa Rica) · Manta (Ecuador) · Guayaquil (Ecuador) · Salaverry (Peru) Ends in Callao (Peru)	Check prices
Tue, Oct 12, 2027 endsTue, Nov 2, 2027	Nieuw Amsterdam	Holland America Line	21	21-Night South America Calls at Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) Ends in San Antonio (Chile)	from $2,784 $133 a night · per person interior, as of 2026-10-23 Lowest fare shown
Tue, Oct 12, 2027 endsWed, Nov 17, 2027	Nieuw Amsterdam	Holland America Line	36	36-Night South America Calls at Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) · San Antonio (Chile) · Puerto Montt (Chile) · Puerto Chacabuco (Chile) · Chilean fjords · Pío XI Glacier (Chile) · Punta Arenas (Chile) · Stanley (Falkland Islands) · Montevideo (Uruguay) Ends in Buenos Aires (Argentina)	from $4,249 $118 a night · per person interior, as of 2026-10-23

JAN
8
Friday · 15 nights
15-Night San Diego to Callao
Crystal Serenity · Crystal
Calls at Cabo San Lucas (Mexico) · Mazatlán (Mexico) · Puerto Vallarta (Mexico) · Acajutla (El Salvador) · Playa Flamingo (Costa Rica) · Puntarenas (Costa Rica) · Manta (Ecuador) · Guayaquil (Ecuador) · Salaverry (Peru)
Ends in Callao (Peru)
Ends Sat, Jan 23, 2027 in Callao
Check prices
OCT
12
Tuesday · 21 nights
21-Night South America
Nieuw Amsterdam · Holland America Line
Calls at Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile)
Ends in San Antonio (Chile)
Ends Tue, Nov 2, 2027 in San Antonio
Lowest fare shown
from $2,784 $133 a night · per person
interior, as of 2026-10-23
OCT
12
Tuesday · 36 nights
36-Night South America
Nieuw Amsterdam · Holland America Line
Calls at Cabo San Lucas (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Manta (Ecuador) · Salaverry (Peru) · Callao (Peru) · General San Martin (Peru) · Arica (Chile) · Coquimbo (Chile) · San Antonio (Chile) · Puerto Montt (Chile) · Puerto Chacabuco (Chile) · Chilean fjords · Pío XI Glacier (Chile) · Punta Arenas (Chile) · Stanley (Falkland Islands) · Montevideo (Uruguay)
Ends in Buenos Aires (Argentina)
Ends Wed, Nov 17, 2027 in Buenos Aires
from $4,249 $118 a night · per person
interior, as of 2026-10-23

By month

January 2027 1 October 2027 2

Other destinations from San Diego

Baja and Ensenada 119 sailings · from $219.19 Mexican Riviera and Sea of Cortez 65 sailings · from $419 Pacific coast 19 sailings · from $399 Hawaii and South Pacific 15 sailings · from $1,699 Panama Canal 11 sailings · from $1,699

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-10-23. Fares change often, so check the current price before you book.

Other itineraries from San Diego: questions

How many Other itineraries cruises leave San Diego?

3 departures across 2 months, on 2 ships from Crystal and Holland America Line.

How long are Other itineraries cruises from San Diego?

From 15 to 36 nights.

Which ports do they call at?

Most commonly Cabo San Lucas (Mexico) (3 sailings), Puntarenas (Costa Rica) (3 sailings), Manta (Ecuador) (3 sailings), Salaverry (Peru) (3 sailings), and Huatulco (Mexico) (2 sailings).