Destination

Panama Canal cruises from San Diego

One-way trips through the canal, most of them ending in Miami, Fort Lauderdale, Tampa or Galveston. On the way they call along the Mexican and Central American coast, at places like Puerto Vallarta, Puerto Quetzal in Guatemala and Puntarenas in Costa Rica, and then at Cartagena in Colombia. Azamara's longest carries on across the Atlantic to England.

There are 11 such sailings on the board, running 14 to 35 nights, operated by Disney Cruise Line, Holland America Line, Princess Cruises, Norwegian Cruise Line, Azamara, and Royal Caribbean International aboard Disney Magic, Zaandam, Island Princess, Zuiderdam, Norwegian Star, Azamara Quest, Eurodam, and Serenade of the Seas. The lowest recorded starting fare is $1,699 per person, on the Sat, Jan 30, 2027 departure.

Ports of call

Panama Canal10 Puerto Vallarta (Mexico)9 Cartagena (Colombia)9 Cabo San Lucas (Mexico)8 Puntarenas (Costa Rica)8 Puerto Quetzal (Guatemala)7 Huatulco (Mexico)5 Grand Cayman3 Puerto Chiapas (Mexico)3 Fuerte Amador (Panama)3 Aruba2 Acapulco (Mexico)2 Acajutla (El Salvador)2 Half Moon Cay (Bahamas)1 Panama City (Panama)1 Miami (Florida)1 New York (New York)1 Newport (Rhode Island)1 Cape Cod (Massachusetts)1 Boston (Massachusetts)1 Halifax (Nova Scotia)1 St. John's (Newfoundland)1 Cobh (Ireland)1 Plymouth (England)1 Le Havre (France)1 Manzanillo (Mexico)1

Schedule last updated 2026-10-23 · 11 departures listed · Dates can change. Verify with the cruise line before booking.

Your Panama Canal options

All routes

The 11 departures below run a smaller number of distinct itineraries. Cheapest per night first.

Distinct itineraries available, cheapest per night first
Itinerary	Ship	Nights	Departures	From
16-Night Repositioning Calls at Cabo San Lucas (Mexico) · Acapulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama City (Panama) · Panama Canal · Cartagena (Colombia) · Grand Cayman Ends in Miami (Florida) Next on Sat, Feb 13, 2027	Norwegian Star	16	1	$1,709$107 a night
15-Night Panama Canal Calls at Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puerto Quetzal (Guatemala) · Fuerte Amador (Panama) · Cartagena (Colombia) · Half Moon Cay (Bahamas) Ends in Miami (Florida) Next on Sat, Jan 30, 2027	Zuiderdam, Zaandam	15	2	$1,699$113 a night
16-Night Transcanal Calls at Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puntarenas (Costa Rica) · Fuerte Amador (Panama) · Panama Canal · Aruba Ends in Fort Lauderdale (Florida) Next on Fri, Jan 29, 2027	Island Princess	16	1	$1,919$120 a night
15-Night Panama Canal Eastward Calls at Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) · Grand Cayman Ends in Tampa (Florida) Next on Thu, Oct 7, 2027	Serenade of the Seas	15	1	$2,259.27$151 a night
16-Night Panama Canal Calls at Cabo San Lucas (Mexico) · Acapulco (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Aruba Ends in Fort Lauderdale (Florida) Next on Thu, Oct 7, 2027	Eurodam	16	1	$2,769$173 a night
14-Night Panama Canal Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Panama Canal · Cartagena (Colombia) · Grand Cayman Ends in Galveston (Texas) Next on Fri, Nov 6, 2026	Disney Magic	14	2	$2,477$177 a night
17-Night South America Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Acajutla (El Salvador) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) Ends in Miami (Florida) Next on Mon, May 24, 2027	Azamara Quest	17	1	$4,089$241 a night
35-Night Grand Voyage Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Acajutla (El Salvador) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) · Miami (Florida) · New York (New York) · Newport (Rhode Island) · Cape Cod (Massachusetts) · Boston (Massachusetts) · Halifax (Nova Scotia) · St. John's (Newfoundland) · Cobh (Ireland) · Plymouth (England) · Le Havre (France) Ends in Tilbury (England) Next on Mon, May 24, 2027	Azamara Quest	35	1	$9,949$284 a night

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-10-23. Fares change often, so check the current price before you book.

Every departure by date

Panama Canal sailings from the Port of San Diego
Departs	Ship	Line	Nights	Itinerary & ports	From
Fri, Nov 6, 2026 endsFri, Nov 20, 2026	Disney Magic	Disney Cruise Line	14	14-Night Panama Canal Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Panama Canal · Cartagena (Colombia) · Grand Cayman Ends in Galveston (Texas)	from $2,477 $177 a night · per person interior, as of 2026-10-23
Sat, Dec 19, 2026 endsSun, Jan 3, 2027	Zaandam	Holland America Line	15	15-Night Panama Canal Holiday Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) Ends in Fort Lauderdale (Florida)	Check prices
Fri, Jan 29, 2027 endsSun, Feb 14, 2027	Island Princess	Princess Cruises	16	16-Night Transcanal Calls at Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puntarenas (Costa Rica) · Fuerte Amador (Panama) · Panama Canal · Aruba Ends in Fort Lauderdale (Florida)	from $1,919 $120 a night · per person interior, as of 2026-10-23
Sat, Jan 30, 2027 endsSun, Feb 14, 2027	Zuiderdam	Holland America Line	15	15-Night Panama Canal Calls at Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puerto Quetzal (Guatemala) · Fuerte Amador (Panama) · Cartagena (Colombia) · Half Moon Cay (Bahamas) Ends in Miami (Florida)	from $1,699 $113 a night · per person interior, as of 2026-10-23 Lowest fare shown
Sat, Feb 13, 2027 endsMon, Mar 1, 2027	Norwegian Star	Norwegian Cruise Line	16	16-Night Repositioning Calls at Cabo San Lucas (Mexico) · Acapulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama City (Panama) · Panama Canal · Cartagena (Colombia) · Grand Cayman Ends in Miami (Florida) Sources disagree, verify with the line	from $1,709 $107 a night · per person interior, as of 2026-10-23
Mon, May 24, 2027 endsThu, Jun 10, 2027	Azamara Quest	Azamara	17	17-Night South America Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Acajutla (El Salvador) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) Ends in Miami (Florida)	from $4,089 $241 a night · per person interior, as of 2026-10-23
Mon, May 24, 2027 endsMon, Jun 28, 2027	Azamara Quest	Azamara	35	35-Night Grand Voyage Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Acajutla (El Salvador) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) · Miami (Florida) · New York (New York) · Newport (Rhode Island) · Cape Cod (Massachusetts) · Boston (Massachusetts) · Halifax (Nova Scotia) · St. John's (Newfoundland) · Cobh (Ireland) · Plymouth (England) · Le Havre (France) Ends in Tilbury (England)	from $9,949 $284 a night · per person ocean view, as of 2026-10-23
Thu, Oct 7, 2027 endsSat, Oct 23, 2027	Eurodam	Holland America Line	16	16-Night Panama Canal Calls at Cabo San Lucas (Mexico) · Acapulco (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Aruba Ends in Fort Lauderdale (Florida)	from $2,769 $173 a night · per person interior, as of 2026-10-23
Thu, Oct 7, 2027 endsFri, Oct 22, 2027	Serenade of the Seas	Royal Caribbean International	15	15-Night Panama Canal Eastward Calls at Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) · Grand Cayman Ends in Tampa (Florida)	from $2,259.27 $151 a night · per person lowest available fare, as of 2026-10-23
Thu, Nov 4, 2027 endsThu, Nov 18, 2027	Disney Magic	Disney Cruise Line	14	14-Night Panama Canal Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Fuerte Amador (Panama) · Panama Canal · Cartagena (Colombia) Ends in Galveston (Texas)	from $2,701 $193 a night · per person interior, as of 2026-10-23
Sat, Dec 18, 2027 endsSun, Jan 2, 2028	Zaandam	Holland America Line	15	15-Night Panama Canal Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Manzanillo (Mexico) · Huatulco (Mexico) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) Ends in Miami (Florida)	from $2,674 $178 a night · per person interior, as of 2026-10-23

NOV
6
Friday · 14 nights
14-Night Panama Canal
Disney Magic · Disney Cruise Line
Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Panama Canal · Cartagena (Colombia) · Grand Cayman
Ends in Galveston (Texas)
Ends Fri, Nov 20, 2026 in Galveston
from $2,477 $177 a night · per person
interior, as of 2026-10-23
DEC
19
Saturday · 15 nights
15-Night Panama Canal Holiday
Zaandam · Holland America Line
Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia)
Ends in Fort Lauderdale (Florida)
Ends Sun, Jan 3, 2027 in Fort Lauderdale
Check prices
JAN
29
Friday · 16 nights
16-Night Transcanal
Island Princess · Princess Cruises
Calls at Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puntarenas (Costa Rica) · Fuerte Amador (Panama) · Panama Canal · Aruba
Ends in Fort Lauderdale (Florida)
Ends Sun, Feb 14, 2027 in Fort Lauderdale
from $1,919 $120 a night · per person
interior, as of 2026-10-23
JAN
30
Saturday · 15 nights
15-Night Panama Canal
Zuiderdam · Holland America Line
Calls at Puerto Vallarta (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puerto Quetzal (Guatemala) · Fuerte Amador (Panama) · Cartagena (Colombia) · Half Moon Cay (Bahamas)
Ends in Miami (Florida)
Ends Sun, Feb 14, 2027 in Miami
Lowest fare shown
from $1,699 $113 a night · per person
interior, as of 2026-10-23
FEB
13
Saturday · 16 nights
16-Night Repositioning
Norwegian Star · Norwegian Cruise Line
Calls at Cabo San Lucas (Mexico) · Acapulco (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama City (Panama) · Panama Canal · Cartagena (Colombia) · Grand Cayman
Ends in Miami (Florida)
Sources disagree, verify
Ends Mon, Mar 1, 2027 in Miami
from $1,709 $107 a night · per person
interior, as of 2026-10-23
MAY
24
Monday · 17 nights
17-Night South America
Azamara Quest · Azamara
Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Acajutla (El Salvador) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia)
Ends in Miami (Florida)
Ends Thu, Jun 10, 2027 in Miami
from $4,089 $241 a night · per person
interior, as of 2026-10-23
MAY
24
Monday · 35 nights
35-Night Grand Voyage
Azamara Quest · Azamara
Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Acajutla (El Salvador) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) · Miami (Florida) · New York (New York) · Newport (Rhode Island) · Cape Cod (Massachusetts) · Boston (Massachusetts) · Halifax (Nova Scotia) · St. John's (Newfoundland) · Cobh (Ireland) · Plymouth (England) · Le Havre (France)
Ends in Tilbury (England)
Ends Mon, Jun 28, 2027 in Tilbury
from $9,949 $284 a night · per person
ocean view, as of 2026-10-23
OCT
7
Thursday · 16 nights
16-Night Panama Canal
Eurodam · Holland America Line
Calls at Cabo San Lucas (Mexico) · Acapulco (Mexico) · Huatulco (Mexico) · Puerto Chiapas (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Aruba
Ends in Fort Lauderdale (Florida)
Ends Sat, Oct 23, 2027 in Fort Lauderdale
from $2,769 $173 a night · per person
interior, as of 2026-10-23
OCT
7
Thursday · 15 nights
15-Night Panama Canal Eastward
Serenade of the Seas · Royal Caribbean International
Calls at Puerto Vallarta (Mexico) · Puerto Quetzal (Guatemala) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia) · Grand Cayman
Ends in Tampa (Florida)
Ends Fri, Oct 22, 2027 in Tampa
from $2,259.27 $151 a night · per person
lowest available fare, as of 2026-10-23
NOV
4
Thursday · 14 nights
14-Night Panama Canal
Disney Magic · Disney Cruise Line
Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Fuerte Amador (Panama) · Panama Canal · Cartagena (Colombia)
Ends in Galveston (Texas)
Ends Thu, Nov 18, 2027 in Galveston
from $2,701 $193 a night · per person
interior, as of 2026-10-23
DEC
18
Saturday · 15 nights
15-Night Panama Canal
Zaandam · Holland America Line
Calls at Cabo San Lucas (Mexico) · Puerto Vallarta (Mexico) · Manzanillo (Mexico) · Huatulco (Mexico) · Puntarenas (Costa Rica) · Panama Canal · Cartagena (Colombia)
Ends in Miami (Florida)
Ends Sun, Jan 2, 2028 in Miami
from $2,674 $178 a night · per person
interior, as of 2026-10-23

By month

November 2026 1 December 2026 1 January 2027 2 February 2027 1 May 2027 2 October 2027 2 November 2027 1 December 2027 1

Other destinations from San Diego

Baja and Ensenada 119 sailings · from $219.19 Mexican Riviera and Sea of Cortez 65 sailings · from $419 Pacific coast 19 sailings · from $399 Hawaii and South Pacific 15 sailings · from $1,699 Other itineraries 3 sailings · from $2,784

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-10-23. Fares change often, so check the current price before you book.

Panama Canal from San Diego: questions

How many Panama Canal cruises leave San Diego?

11 departures across 8 months, on 8 ships from Disney Cruise Line, Holland America Line, Princess Cruises, Norwegian Cruise Line, Azamara, and Royal Caribbean International.

How long are Panama Canal cruises from San Diego?

From 14 to 35 nights.

Which ports do they call at?

Most commonly Panama Canal (10 sailings), Puerto Vallarta (Mexico) (9 sailings), Cartagena (Colombia) (9 sailings), Cabo San Lucas (Mexico) (8 sailings), and Puntarenas (Costa Rica) (8 sailings).