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San Diego Cruise Schedule
Serenade of the Seas docked in Halifax, Nova Scotia, in 2024

Serenade of the Seas / Royal Caribbean International

15-Night Panama Canal Eastward from San Diego

Nights
15
Ports of call
6
Departures
1
From
$2,259.27

Serenade of the Seas sails this route from the Port of San Diego 1 time in the window we track. Each one runs 15 nights. It finishes in Tampa (Florida) rather than back in San Diego, so check flights home before you book.

The ship calls at Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama Canal, Cartagena (Colombia), and Grand Cayman. We record which ports a sailing visits, not the order it visits them in, because the running order changes from date to date.

The one departure leaves on Thu, Oct 7, 2027. The cheapest recorded starting fare is $2,259.27 per person, which works out at $151 a night.

Schedule last updated 2026-10-23 · 1 departure listed · Dates can change. Verify with the cruise line before booking.

Every departure on this route

Other routes Serenade of the Seas runs

Full ship schedule

Starting fares per person, for the cheapest cabin listed, with taxes and port fees included, checked 2026-10-23. Fares change often, so check the current price before you book.

Same region, different ship

All Panama Canal sailings